Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
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چکیده
منابع مشابه
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
Although a causal role of genetic alterations in human cancer is well established, it is still unclear whether dietary fat can modulate cancer risk in a predisposed population. Epidemiological studies suggest that diets rich in omega-3 polyunsaturated fatty acids reduce cancer incidence. To determine the influence of fatty acids on prostate cancer risk in animals with a defined genetic lesion, ...
متن کاملOmega-3 Fatty Acids and Risk for Prostate Cancer
On July 11, 2013 a paper was published online by Brasky et al. in the J Natl Cancer Institute entitled, “Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial.” The authors found that higher plasma omega-3 fatty acid levels were associated with increased risk for developing prostate cancer. In this study, plasma phospholipid omega-3 levels were measured in 834 men who eve...
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Background: Endometriosis is a common chronic inflammation causing major problems including infertility. The role of omega-3 and omega-6 fatty acids as their potential anti-inflammatory effects in endometriosis needs to be further explored. The objective of this study was to compare serum phospholipid fatty acid profile in endometriosis patients with controls, and to explore the correlation of ...
متن کاملDietary omega-6 and omega-3 fatty acids and prostate cancer - letter.
Recently, Aronson and colleagues (1) reported that men withprostate cancer receiving approximately 5 g/d of fishoil combined with a low-fat diet (15% kcal from fat) for 4 to 6 weeks before prostatectomy had 32% lower tumor ki67 staining compared with men consuming a Western diet (45%kcal from fat). This study is of interest because thedata suggest that dietary modification can greatly reduce tu...
متن کاملDietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.
PURPOSE Dietary intake of long-chain omega-3 (LC n-3) polyunsaturated fatty acids may reduce inflammation and in turn decrease risk of prostate cancer development and progression. This potential effect may be modified by genetic variation in cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation. EXPERIMENTAL DESIGN We used a case-control study of 466 men diagnosed w...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2007
ISSN: 0021-9738
DOI: 10.1172/jci31494